A Prototype Toolkit For Evaluating Indoor Environmental Quality In Commercial Buildings

Measurement of building environmental parameters is often complex, expensive, and not easily proceduralized in a manner that covers all commercial buildings. Evaluating building indoor environmental quality performance is therefore not standard practice. This project developed a prototype toolkit that addressed existing barriers to widespread indoor environmental quality performance evaluation. A toolkit with both hardware and software elements was designed for practitioners around the indoor environmental quality requirements of the American Society of Heating, Refrigeration and Air Conditioning Engineers / Chartered Institution of Building Services / United States Green Building Council Performance Measurement Protocols. This unique toolkit was built on a wireless mesh network with a web-based data collection, analysis, and reporting application. The toolkit provided a fast, robust deployment of sensors, real-time data analysis, Performance Measurement Protocol-based analysis methods and a scorecard and report generation tools. A web-enabled Geographic Information System-based metadata collection system also reduced field-study deployment time. The toolkit was evaluated through three case studies, which were discussed in this report

Phenology and growth response to irrigation and sowing date of Kabuli chickpea (Cicer arietinum L.) in a cool-temperate subhumid climate

The photothermal response of three Kabuli chickpea (Cicer arietinum L.) cultivars, at different growth stages, to eight irrigation treatments in 1998/99 and four irrigation treatments in 1999/2000 was studied on a Wakanui silt loam soil in Canterbury, New Zealand (43°38S, 172°30E). The rate of development from emergence to flowering (e-f) and sowing to harvest maturity were strongly and positively associated (R²=0·87, P<0·001) with mean temperature during those periods. All phenological stages considered (sowing to emergence, e-f, flowering to podding, podding to physiological maturity and physiological maturity to harvest maturity) depended upon accumulated thermal time (Tt) above a base temperature (Tb) of 1 °C. An accurate prediction of time of flowering was made based on an accumulated mean Tt requirement of 629 °Cdays from e-f (R²=0·91, P<0·001). Fully irrigated crops had higher maximum dry matter accumulation (maxDM; 1093 g/m²), duration of exponential growth (DUR; 99 days), weighted mean absolute growth rate (WMAGR; 12·2 g/m² per day) and maximum crop growth rate (MGR; 17·1 g/m² per day). In 1998/99 the positive response of maxDM and MGR depended on a significant (P<0·01) interaction between irrigation and sowing date. The maxDM during the season was highly correlated with DUR and MGR (R²=0·79 and 0·65). It is concluded that to maximize chickpea biological yield in the dry season of the cool-temperate subhumid climate of Canterbury, irrigation should extend across all phenological stages

Oxidative Stress in Parkinson\u27s Disease; Parallels Between Current Animal Models, Human Studies and Cells

Griffith Sciences, Griffith Institute for Drug DiscoveryFull Tex

Factors determining hemoglobin carbamylation in renal failure

Factors determining hemoglobin carbamylation in renal failure. Carbamylated hemoglobin (carhb) is formed by the reaction of hemoglobin with cyanate, a product of in vivo urea dissociation. It is found in high levels in patients with renal failure and may be useful in their clinical evaluation. Accordingly, we measured carhb by HPLC after acid hydrolysis in 73 patients with renal failure and 11 controls. Mean carhb levels, (expressed as μg valine hydantoin/g Hb), were highest in chronic renal failure (CRF, 146 ± 13), intermediate in end-stage renal disease on hemodialysis (ESRD, 106 ± 7), and lowest in acute renal failure (ARF, 80 ± 12) when compared to normal subjects (27 ± 2). In all patients carhb was significantly correlated with BUN but not with creatinine, bicarbonate, or phosphate. For any level of BUN above 80 mg/dl, carhb was substantially higher in CRF than in ARF. Predialysis BUN and urea reduction ratio (URR) were significant predictors of carhb in ESRD. To investigate the effect of time of exposure and BUN level on the rate of carbamylation of hemoglobin, blood from normal subjects and dialysis patients was incubated in vitro with urea equivalent to BUN levels of 50, 100, 150, and 200 mg/dl and assayed for carhb at 0, 5, 9, and 14 days. Carhb increased linearly over the first nine days of urea exposure and leveled off thereafter. The rate of carbamylation increased as BUN increased and was significantly higher in hemoglobin from dialysis patients than from normal subjects. These results show that the higher the level of carhb at baseline, the higher the rate of carbamylation upon exposure to increasing urea concentrations. We conclude that carhb formation is dependent on urea concentration and length of exposure to urea. The rate of carhb formation for a given urea concentration is greater in hemoglobin already carbamylated, and this may explain why carhb is higher in CRF than in ARF at BUN levels greater than 80 mg/dl. Carhb may thus be a useful index of the duration and degree of exposure to high blood urea levels in patients with renal failure, and may potentially serve as an index of the adequacy of dialysis

Gender Recognition from Faces Using Bandlet and Local Binary Patterns

Abstract — In this paper, multi-scale bandlet and local binary pattern (LBP) based method for gender recognition from faces is proposed. Bandlet is one of the multi-resolution techniques that can adapt the orientation of the edges of the face images, and thereby can better capture the texture of a face image. After extracting bandlet coefficients from face images at different scales, LBP is applied to create a histogram, which is used as the feature to a minimum distance classifier. The experiments are performed using FERET grayscale face database, and the highest accuracy of 99.13 % is obtained with the proposed method

Multi-hazard groundwater risks to water supply from shallow depths: challenges to achieving the sustainable development goals in Bangladesh

Background: Groundwater currently provides 98% of all drinking-water supply in Bangladesh. Groundwater is found throughout Bangladesh but its quality (i.e. arsenic and salinity contamination) and quantity (i.e., water-storage depletion) vary across hydrological environments, posing unique challenges to certain geographical areas and population groups. Yet, no national-scale, multi-parameter groundwater hazard maps currently exist enabling water resources managers and policy makers to identify vulnerable areas to public health. Methods: We develop, for the first time, groundwater multi-hazard maps at the national scale of Bangladesh combining information on arsenic, salinity and water storage. We apply geospatial techniques in ‘R’ programming language and ArcGIS environment, linking hydrological indicators for water quality and quantity to construct risk maps. A range of socio-economic variables including access to drinking and irrigation water supplies and social vulnerability (i.e., poverty) are overlaid on these risk maps to estimate exposures. Results: Our multi-parameter groundwater hazard maps show that a considerable proportion of land area (5% to 24% under extremely-high to high risks) in Bangladesh is currently under combined risk of arsenic and salinity contamination, and groundwater-storage depletion. As small as 6.5 million (2.2 million poor) to 24.4 million (8.6 million poor) people are exposed to a combined risk of high arsenic, salinity and groundwater-storage depletion. Conclusions: Our groundwater hazard maps reveal areas and exposure of population groups to water risks posed by arsenic and salinity contamination and depletion of water storage. These geospatial hazard maps can potentially guide policymakers in prioritizing mitigation and adaptation measures in order to achieve the United Nation’s Sustainable Development Goals across the water, agriculture and public health sectors in Bangladesh

Predictors of morbidity and in‐hospital mortality following procedure‐related cardiac tamponade

BACKGROUND: Cardiac tamponade (CT) can be a complication following invasive cardiac procedures. We assessed CT following common cardiac electrophysiology (EP) procedures to facilitate risk prediction of associated morbidity and in-hospital mortality. METHODS: Patients who underwent various EP procedures in the cardiac catheterization lab (ablations and device implantations) were identified using the International Classification of Diseases, Ninth and Tenth Edition, Clinical Modification (ICD-9-CM and ICD-10-CM, respectively) from the Nationwide Inpatient Sample (NIS) database. Patient demographics, presence of comorbidities, CT-related events, and in-hospital death were also abstracted from the NIS database. RESULTS: The frequency of CT-related events in patients with EP intervention from 2010 to 2017 ranged from 3.4% to 7.0%. In-hospital mortality related to CT-related events was found to be 2.2%. Increasing age was the only predictor of higher mortality in atrial fibrillation (AF) ablation and cardiac resynchronization therapy (CRT) groups (OR [95% CI]: AF ablation = 11.15 [1.70–73.34], p = .01; CRT = 1.41 [1.05–1.90], p = .02). CONCLUSIONS: In the real-world setting, CT-related events in EP procedures were found to be 3.4%–7.0% with in-hospital mortality of 2.2%. Older patients undergoing AF ablation were found to have higher mortality

Unaltered myocilin expression in the blood of primary open angle glaucoma patients

PURPOSE: To investigate the expression of the myocilin gene (MYOC) in the blood of primary open angle glaucoma (POAG) patients to determine if altered systemic expression is playing a role. METHODS: Patients (n=47) were eligible for inclusion if they met standard clinical criteria for POAG. Control subjects (n=27) were recruited who were free from glaucoma by examination. RNA was extracted from leukocytes of patients and controls and converted to cDNA by reverse transcriptase enzyme, and quantitative PCR was used to assess expression levels of MYOC and the house keeping gene β-globulin (HBB). The ratio of MYOC expression to HBB expression for POAG patients was compared to that of controls and to clinical characteristics of POAG patients. RESULTS: Mean gene expression values were statistically similar in POAG patients and controls for both MYOC (p≤0.55) and HBB (p≤0.48). MYOC/HBB ratios were also statistically indistinguishable between POAG patients and controls (p≤0.90). MYOC/HBB ratios were not significantly associated with age, sex, or ethnicity of patients within the POAG group. Similarly, MYOC/HBB ratios were not significantly associated with clinical parameters related to POAG severity, including maximum intraocular pressure, vertical cup-to-disk ratio, static perimetry mean deviation, or static perimetry pattern standard deviation. CONCLUSIONS: MYOC expression is not altered in the blood of POAG patients, unlike MYOC expression in trabecular meshwork (TM) cultures. These results suggests that MYOC expression is not altered systemically but rather that MYOC expression may contribute to POAG pathogenesis in specific tissues such as TM